4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid - Names and Identifiers
4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid - Physico-chemical Properties
4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid - Introduction
4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid is an organic compound with the chemical formula C7H4F3N3O2S. Here is some information about its nature, use, formulation and safety:
Nature:
-Appearance: White crystal or crystalline powder
-Melting point: about 132-136 degrees Celsius
-Solubility: Poor solubility in water and common organic solvents, soluble in acidic solutions
-Illustrative structure: Trifluoromethyl is located on the pyrimidine ring, methylthio is located at position 2 of the ring, and carboxylic acid is located at position 5
Use:
- 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid is an important organic synthesis intermediate, often used in the synthesis of other compounds.
-It is often used in the field of medicine as a raw material for the synthesis of specific drugs.
Method:
Generally, the preparation method of 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid includes the following steps:
1.2-Methylthiopyrimidine is reacted with trifluoromethanesulfonic acid to obtain the corresponding trifluoromethyl sulfate.
2. The reaction of trifluoromethyl sulfate with carbonic acid chloride to generate tetrafluoromethyl carboxylic acid.
3. Tetrafluoromethylcarboxylic acid reacts with thiophene, and 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid is obtained by oxidation.
Safety Information:
- 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid is not currently classified as toxic, but is still subject to laboratory safety procedures.
-During operation and storage, care should be taken to prevent contact with skin, eyes and respiratory tract.
-There is no detailed study on the impact on human health and the environment. Please follow relevant regulations and guidelines when using it.
Last Update:2024-04-09 02:00:51